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GCF Levels of IL-1β and IL-6 in Gingivitis and Stage III-Grade C Periodontitis

NCT04689438 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 64

Last updated 2022-11-04

No results posted yet for this study

Summary

Periodontal diseases are chronic diseases that occur as a result of a violation of the balance between microbial dental plaque and the host response. Gingivitis is a disease characterized by inflammation of the gingiva that occurs in one or more areas without loss of attachments.1 in periodontitis, an inflammatory event that begins in the gingiva along with gingivitis spreads to the periodontal ligament, alveolar bone and soft tissues that support the tooth, causing the destruction of these structures.2 Cytokines are low molecular weight proteins that participate in the initial and active stages of inflammation and immunity. In periodontal disease pathogenesis, cytokine response has been reported to play a very critical role in determining disease progression.3 IL-1beta and IL-6 are key cytokines in chronic inflammatory diseases and have the potential to initiate bone loss and tissue destruction seen in periodontal disease.4the purpose of this study; it is to determine the degree of inflammation and periodontal destruction by determining the levels of IL-1beta and IL-6 cytokines in the gingival crevicular fluid of periodontal healthy and diseased individuals.

Conditions

  • Periodontitis

Interventions

DIAGNOSTIC_TEST

gingival crevicular fluid

GCF samples were collected in the morning hours 24-48 hours after clinical periodontal measurement.

Sponsors & Collaborators

  • Uşak University

    lead OTHER

Principal Investigators

  • ahu dikilitaş · University of Usak

  • fatih karaaslan · University of Usak

  • abdullah seçkin ertuğrul · University of IZMIR KATİP CELEBİ

Eligibility

Min Age
20 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-10-08
Primary Completion
2020-12-25
Completion
2020-12-28

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04689438 on ClinicalTrials.gov