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Neuroendocrine Response to Oral Alcohol Administration

NCT03165942 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2022-08-04

No results posted yet for this study

Summary

This study proposes to examine both the peripheral and central nervous system responses when light social drinkers and binge/heavy social drinkers are exposed to oral ethanol. The findings will provide a greater understanding of the brain mechanisms (cerebral blood flow and functional connectivity) underlying the association between stress, cortisol release, heart rate variability, alcohol craving, and alcohol stimulant and sedative effects. This knowledge could be significant in developing new therapies for the treatment of alcoholism.

Conditions

  • Alcohol Abuse

Interventions

OTHER

Alcoholic Beverage

In addition to the oral delivery, an IV line will be placed for the purpose of drawing blood during the MRI session.

OTHER

Non-Alcoholic Beverage

In addition to the oral delivery, an IV line will be placed for the purpose of drawing blood during the MRI session.

DRUG

Ethanol

Sponsors & Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    collaborator NIH

  • Yale University

    lead OTHER

Principal Investigators

  • Sara Blaine, PhD · Addictions, Division of Yale Stress Center

  • Rajita Sinha, PhD · Professor of Psychiatry, Yale Center for Clinical Investigation

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-09-08
Primary Completion
2018-06-30
Completion
2018-06-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03165942 on ClinicalTrials.gov