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Rate-limiting Amino Acids in Endurance-trained Athlete

NCT02628249 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 5

Last updated 2019-04-01

No results posted yet for this study

Summary

Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).

The biological value of protein depends on the amino acid composition. As liebig's law of the minimum, the protein synthesis is limited due to the lack of single rate limiting amino acid. In this case, the first rate limiting amino acid determines protein intakes to maximize the protein synthesis. Adding a small amount of rate-limiting amino acid to the diet improves the biological value of its protein diet.

The indicator amino acid oxidation (IAAO) method has clarified the individual amino acid requirement in children, normal healthy adult and clinical populations. however, the IAAO method has never been utilized for determining the first rate limiting amino acid.

Therefore, the purpose of this study is to address of IAAO method to be applied for determining the rate-limiting amino acid in endurance athlete.

Conditions

  • Increased Metabolic Requirement
  • Healthy

Interventions

DIETARY_SUPPLEMENT

Base protein

0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein

DIETARY_SUPPLEMENT

Sufficient protein

1.75 g/kg/d protein provided as crystalline amino acid modeled after egg protein.

DIETARY_SUPPLEMENT

Branched chain amino acids

Branched chain amino acids modeled after egg protein.

DIETARY_SUPPLEMENT

Essential amino acids

Essential amino acids modeled after egg protein.

DIETARY_SUPPLEMENT

Non essential amino acids

Non essential amino acids modeled after egg protein.

Sponsors & Collaborators

  • University of Toronto

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-09-30
Primary Completion
2017-06-30
Completion
2017-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02628249 on ClinicalTrials.gov