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Essential Amino Acids and Protein Kinetics During Caloric Deprivation

NCT03372928 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2020-11-20

Study results available
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Summary

The amount of essential amino acids (EAA) necessary to maximally stimulate muscle protein synthesis and optimize whole-body net protein balance during caloric deprivation has not been determined. This study will address that gap in knowledge by examining the resting and post-exercise muscle and whole-body protein kinetic responses to ingesting varying amounts of EAA after a 5 day period of negative energy balance. This study will provide the initial evidence to support the development of a recovery-based food product for military combat rations.

Conditions

  • Muscle Protein Synthesis
  • Whole-body Protein Balance

Interventions

DIETARY_SUPPLEMENT

Standard EAA

EAA provided relative to body mass at a standard dose (0.10 g/kg) during energy deprivation

DIETARY_SUPPLEMENT

High EAA

EAA provided relative to body mass at a high dose (0.30 g/kg) during energy deprivation

Sponsors & Collaborators

  • University of Arkansas

    collaborator OTHER

  • Eastern Michigan University

    collaborator OTHER

  • United States Army Research Institute of Environmental Medicine

    lead FED

Principal Investigators

  • Stefan M Pasiakos, PhD · Military Nutrition Division, USARIEM

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-09-01
Primary Completion
2019-03-20
Completion
2019-03-20

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03372928 on ClinicalTrials.gov