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Essential Amino Acids Supplementation and Muscle Protein Synthesis

NCT01366924 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 23

Last updated 2017-07-21

No results posted yet for this study

Summary

The modern warfighter faces numerous physiological challenges including sleep deprivation, sustained intense physical activity, and caloric restriction, the combined effects of which may result in the loss of lean body mass and decreased physical performance. Dietary interventions may help preserve lean body mass and facilitate recovery from periods of intense physical demand. For example, dietary strategies that increase amino acid availability have been shown to stimulate protein synthesis in skeletal muscle following resistance exercise. Because military tasks also incorporate endurance exercise components, studies regarding the effects of increasing dietary amino acids following endurance exercise are warranted. The objectives of this study are to characterize the effect of endurance exercise on protein synthesis and breakdown as well as the ability of an essential amino acid supplement to influence skeletal muscle protein metabolism and its cellular and molecular regulation following endurance exercise.

Conditions

  • Muscle Loss
  • Muscle Anabolism

Interventions

DIETARY_SUPPLEMENT

Essential Amino Acids

10 Gram Essential Amino Acid solutions with different leucine contents consumed during two identical endurance exercise trials

OTHER

Endurance exercise

60 minute endurance exercise session

Sponsors & Collaborators

  • Tufts University

    collaborator OTHER

  • United States Army Research Institute of Environmental Medicine

    lead FED

Principal Investigators

  • Stefan M Pasiakos, Ph.D. · US Army Research Institute of Environmental Medicine

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-05-31
Primary Completion
2010-07-31
Completion
2010-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01366924 on ClinicalTrials.gov