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Development of Oral Amino Acid Tracers to Study Protein Turnover in Humans

NCT04887727 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2021-05-14

No results posted yet for this study

Summary

Previous studies have used a combination of oral L-\[1-13C\]leucine and intravenous labeled L-\[5,5,5-2H3\]leucine to assess the acute postprandial changes in whole-body protein turnover (12, 19). Intravenous and dietary-labeled amino acid tracers have also been used in tandem to assess rates of myofibrillar protein synthesis in response to bolus protein ingestion and resistance exercise (46). By validating whole-body net balance to myofibrillar protein synthesis, our proposed multi-tracer approach will develop minimally invasive models to study protein turnover in a variety of populations in which traditional infusions and/or repeated blood samples are not possible (i.e. pediatric, free-living populations).

Conditions

  • Healthy Adult Males

Interventions

DIETARY_SUPPLEMENT

Crystalline amino acids to assess myofibrillar protein synthesis rates

Amino acid dose = 0.25g/kg bodyweight

DIETARY_SUPPLEMENT

Crystalline amino acids to assess whole-body protein turnover, amino acid oxidation, and net protein balance

Amino acid dose = 0.25g/kg bodyweight

Sponsors & Collaborators

  • University of Toronto

    lead OTHER

Principal Investigators

  • Daniel R Moore, PhD · University of Toronto

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-02-25
Primary Completion
2019-08-31
Completion
2019-08-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04887727 on ClinicalTrials.gov