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Investigation on the Sustained Effect of Anthocyanins on Endothelial Function in Postmenopausal Women

NCT02517801 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2015-11-03

No results posted yet for this study

Summary

Anthocyanins are the most common polyphenols in berries and red wine, along with other flavonoids, phenolic acids, minerals and vitamins. Anthocyanins are extensively metabolized and they are transformed into glucuronides and phenolic acids. The investigators have recently shown that the acute consumption of blueberries leads to an increase in endothelium-dependent vasodilation measured as flow-mediated dilatation (FMD) in young male volunteers. There were significant correlations of these effects with the plasma concentration of phenolic acids and anthocyanin metabolites. Therefore, the present study aims at understanding to which extent the anthocyanins contained in berries are related with positive effects in endothelial function. A large part of the absorbed anthocyanin circulate in the blood in as methyl, glucuronyl and sulfate metabolites, as well as phenolic acids. The formation of these metabolites begins right as early as 2h after consumption due to metabolism at the small intestine and a second plasmatic peak occurs around 6h due the metabolism of colonic bacteria. Whether and which metabolites are associated with biological effects and the mechanisms underlying this effect remains unclear.

Conditions

  • Post-menopausal Women

Interventions

DIETARY_SUPPLEMENT

Anthocyanin capsules

Chronic intake of 2 capsules for 30 days (2x daily). Capsules with 80 mg of anthocyanins.

DIETARY_SUPPLEMENT

placebo capsules

Chronic intake of 2 capsules for 30 days (2x daily). 2 capsules devoid of anthocyanins.

Sponsors & Collaborators

  • Heinrich-Heine University, Duesseldorf

    lead OTHER

Principal Investigators

  • Ana Rodriguez-Mateos, PhD · Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital Duesseldorf

  • Christian Heiss, MD · Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital Duesseldorf

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-01-31
Primary Completion
2015-09-30
Completion
2015-09-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02517801 on ClinicalTrials.gov