Effects of Cranberry Consumption in Vascular Function in Healthy Individuals

Summary

Accumulating evidence from epidemiological and human intervention studies indicates that the cardiovascular health benefits of diets rich in fruits and vegetables are (in part) related to their (poly)phenol content. Cranberries are rich in (poly)phenols compounds, in particular anthocyanins, but also phenolic acids. At present, a small number of randomized controlled trials investigating the effects of berry (poly)phenols on validated surrogate markers of cardiovascular disease risk has shown promising results. However, to date, very few human studies have specifically investigated the effects of cranberry (poly)phenols on cardiovascular function in healthy subjects. To our knowledge, no study has investigated the time and intake-dependent effect of cranberry consumption on vascular function in healthy subjects. This information is necessary for the planning of long-term studies aiming to assess the potential beneficial effects of cranberries, using optimal amounts at optimal time points. Therefore, this study aims to investigate the potential role of cranberry (poly)phenols in the modulation of vascular function by monitoring changes in vascular function together with the major (poly)phenol derivatives/metabolites in plasma and urine.

Conditions

• Healthy Men

Interventions

DIETARY_SUPPLEMENT

Cranberry 320

Dietary Supplement: Cranberry beverage with 320 mg of (poly)phenols Acute intake of 500 mL (1x daily)

DIETARY_SUPPLEMENT

Cranberry 640

Dietary Supplement: Cranberry beverage with 640 mg of (poly)phenols Acute intake of 500 mL (1x daily)

DIETARY_SUPPLEMENT

Cranberry 960

Dietary Supplement: Cranberry beverage with 960 mg of (poly)phenols Acute intake of 500 mL (1x daily)

DIETARY_SUPPLEMENT

Cranberry 1280

Dietary Supplement: Cranberry beverage with 1280 mg of (poly)phenols Acute intake of 500 mL (1x daily)

DIETARY_SUPPLEMENT

Cranberry 1600

Dietary Supplement: Cranberry beverage with 1600 mg of (poly)phenols Acute intake of 500 mL (1x daily)

DIETARY_SUPPLEMENT

Cranberry deprived supplement

Cranberry deprived supplement Acute intake of 500 mL (1x daily)

Sponsors & Collaborators

• The Cranberry Institute

  collaborator OTHER

• Heinrich-Heine University, Duesseldorf

  lead OTHER

Principal Investigators

• Ana Rodriguez-Mateos, PhD · Division of Cardiology, Pulmonology and Vascular Medicine

• Christian Heiss, MD · Division of Cardiology, Pulmonology and Vascular Medicine

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

40 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-10-31

Primary Completion

2015-09-30

Completion

2015-09-30

Countries

• Germany

Study Locations