Effects of Acute Red Raspberry Consumption on Vascular Function in Healthy Individuals

Summary

Accumulating evidence from epidemiological and human intervention studies indicates that the cardiovascular health benefits of diets rich in fruits and vegetables are (in part) related to their (poly)phenol content. Raspberries are rich in phenolic and polyphenolic compounds, in particular procyanidins, ellagitannins and anthocyanins, but also phenolic acids. At present, a small number of randomized controlled trials investigating the effects of berry (poly)phenols on validated surrogate markers of cardiovascular disease risk have shown promising results. However, to date, very few human studies have specifically investigated the effects of raspberry (poly)phenols on cardiovascular function in healthy subjects. Moreover, ellagitannin-derived metabolites are believed to persist for a long period of time in the blood and urine. Therefore, the investigators will investigate the presence of plasma and urinary raspberry-derived metabolites 24h post-consumption. To the investigators knowledge, the effects of red raspberry consumption on vascular function in humans have not been investigated before. This information is necessary for the planning of long-term studies aiming to assess the potential beneficial effects of raspberries,. Therefore, this study aims to investigate the potential role of red raspberry (poly)phenols in the modulation of vascular function by monitoring changes in vascular function together with the major (poly)phenol derivatives/metabolites in plasma.

Conditions

• Healthy

Interventions

DIETARY_SUPPLEMENT

400 g frozen raspberries

1x daily intake of 600 mL red raspberry beverage

DIETARY_SUPPLEMENT

200 g frozen raspberries

1x daily intake of 600 mL red raspberry beverage

DIETARY_SUPPLEMENT

Placebo

1x daily intake of 600 mL raspberry deprived supplement

Sponsors & Collaborators

• Heinrich-Heine University, Duesseldorf

  lead OTHER

Principal Investigators

• Ana Rodriguez-Mateos, PhD · Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Duesseldorf

• Christian Heiss, MD · Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Duesseldorf

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

40 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-03-31

Primary Completion

2016-09-30

Completion

2016-09-30

Countries

• Germany

Study Locations