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Investigating the Acute Effects of Flavonoids in Blueberries on Cognitive Function.

NCT01289860 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 47

Last updated 2013-02-21

No results posted yet for this study

Summary

This study was a controlled, cross-over, acute flavonoid intervention trial with younger and older adults. Subjects consumed a blueberry beverage during one visit and a control beverage on another. Cognitive function pre drink was assessed, blood and urine samples were taken as well as blood pressure and a measure of vascular reactivity. These outcome measures were taken at 2 and 5 hours post drink.

It was predicted that the flavonoids in the blueberry drink would lead to improved performance on the cognitive tests and vascular reactivity measure compared to following the control drink. It was thought this could be due to increased vaso-dilation and improving blood flow to the brain which was investigated in an extension to the project where a sample of individuals underwent brain imaging in an MRI scanner pre and post a blueberry and a control drink.

Conditions

  • Healthy Adults.

Interventions

DIETARY_SUPPLEMENT

Flavonoids

475g of anthocyanidins in 300ml of blueberry drink.

DIETARY_SUPPLEMENT

Control

29g powder: sugars (glucose, sucrose, fructose), vitamin C and citric acid.

Sponsors & Collaborators

  • University of Reading

    lead OTHER

Principal Investigators

  • Jeremy PE Spencer, PhD · University of Reading

  • Laurie T Butler, PhD · University of Reading

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-05-31
Primary Completion
2013-01-31
Completion
2013-01-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01289860 on ClinicalTrials.gov