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Effects of Blueberry-polyphenols on Endothelial Function, Absorption and Metabolism

NCT02520830 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2015-11-03

No results posted yet for this study

Summary

Diets rich in fruits and vegetables have been linked to favorable cardiovascular outcomes in epidemiological studies.

Dietary intervention studies with certain micronutrients have shown promising effects on surrogate parameters of vascular risk including blood pressure, endothelial function and cholesterol levels. Wild blueberries have gained attention due to their high content of phytochemicals and particularly anthocyanins. Whether wild blueberries can improve vascular function and health when given over relevant time periods and in relevant populations is not known. Therefore, it is the overall hypothesis of the study proposal that chronic consumption of wild blueberries can improve endothelial function, a prognostically validated surrogate of cardiovascular risk.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

Blueberry Group

22 grams freeze-dried blueberry powder per day. Sustained intake (2x 11 grams daily over 1 month) of a drink consisting on freeze-dried wild blueberry powder dissolved in water

DIETARY_SUPPLEMENT

Placebo Group

Sustained intake (2x 11 grams daily over 1 month) of a drink consisting in placebo powder dissolved in water

Sponsors & Collaborators

  • Heinrich-Heine University, Duesseldorf

    lead OTHER

Principal Investigators

  • Ana Rodriguez-Mateos, PhD · Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Duesseldorf

  • Christian Heiss, MD · Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Duesseldorf

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-03-31
Primary Completion
2015-09-30
Completion
2015-09-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02520830 on ClinicalTrials.gov