Effect of MCT Emulsification on Ketogenesis in Human Adults

Summary

Lower brain glucose uptake is present before the onset of cognitive deterioration and may increase the risk of cognitive decline in Alzheimer's disease. Ketones are the brain's main alternative energy substrates. Medium-chain triglycerides (MCT) are rapidly beta-oxidized and are ketogenic. Large doses of MCT oil are linked to gastro-intestinal side effects due to incomplete absorption so the investigators examined whether homogenisation into a skim milk matrix (MCT-H) would both improve ketogenesis and reduce side-effects compared to MCT taken without homogenisation into a matrix (bulk MCT \[MCT-B\]).

Hypotheses: (i) MCT-H will be better absorbed compared to MCT-B, so MCT-H will result in higher ketonemia and lower side effects in healthy adults. (ii) The effects of MCT-B and MCT-H on ketogenesis will be dose-dependent.

Conditions

• Healthy

Interventions

DIETARY_SUPPLEMENT

MCT oil 10g

10 g of pure MCT oil mixed with skim milk in a standardized breakfast

DIETARY_SUPPLEMENT

MCT homogenate 10g

10g provided by 10% MCT homogenate mixed with skim milk in a standardized breakfast

DIETARY_SUPPLEMENT

Control

vehicule (skim milk) with a standardized breakfast

DIETARY_SUPPLEMENT

MCT oil 20g

20g of pure MCT oil mixed with skim milk in a standardized breakfast

DIETARY_SUPPLEMENT

MCT homogenate 20g

20g provided by 10% MCT homogenate mixed with skim milk in a standardized breakfast

DIETARY_SUPPLEMENT

MCT oil 30g

30g of 100% pure MCT oil mixed with skim milk in a standardized breakfast

DIETARY_SUPPLEMENT

MCT homogenate 30g

30g provided by 10% MCT homogenate mixed with skim milk in a standardized breakfast

Sponsors & Collaborators

• Université de Sherbrooke

  lead OTHER

Principal Investigators

• Stephen C Cunnane, PhD · Université de Sherbrooke

Study Design

Allocation

NA

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-07-31

Primary Completion

2014-09-30

Completion

2014-09-30