Canola Oil Multicentre Intervention Trial

Summary

The purpose of the study is to examine how the consumption of different dietary oil varieties affects a broad range of metabolic responses that are important in the development of cardiovascular diseases. This study will examine the relationship between dietary oil consumption and arterial function, blood fat content, and blood markers of cardiovascular disease risk. Additionally, the efficiency of the body in converting fat from dietary oils into other specific fat compounds with know health benefits will be examined. Also, the correlation between psychosocial parameters and vascular function will be studied.

Conditions

• Metabolic Syndrome

Interventions

OTHER

Corn and safflower oil

The oil (60 g/d/3000 kcal) is given in two daily fruit shakes for 4 weeks

OTHER

Canola oil

The oil (60 g/d/3000 kcal providing 3.8 g ALA) is given in two daily fruit shakes for 4 weeks

OTHER

High oleic acid canola oil

The oil (60 g/d/3000 kcal providing 41.2 g oleic acid and 1.2 g ALA) is given in two daily fruit shakes for 4 weeks

OTHER

DHA enriched high oleic acid canola oil

The oil (60 g/d/3000 kcal providing 1.2 g of ALA and 3.6 g of DHA) is given in two daily fruit shakes for 4 weeks

OTHER

Flax and safflower oil

The oil (60 g/d/3000 kcal providing 6.9 g of ALA) is given in two daily fruit shakes for 4 weeks

Sponsors & Collaborators

• University of Toronto

  collaborator OTHER

• Penn State University

  collaborator OTHER

• Laval University

  collaborator OTHER

• University of Manitoba

  lead OTHER

Principal Investigators

• Peter JH Jones, PhD · University of Manitoba

• David Jenkins, PhD · University of Toronto

• Penny Kris-Etherton, PhD, RD · Penn State University

• Sheila West, PhD · Penn State University

• Benoit Lamarche, PhD · Laval University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-09-30

Primary Completion

2012-03-31

Completion

2012-04-30

Countries

• Canada

Study Locations