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Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance With Age; the Role of Amino Acids in Modulating Muscle Metabolism

NCT01735539 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2014-01-17

No results posted yet for this study

Summary

The investigators plan to measure changes in muscle protein metabolism in response to feeding, comparing between a single large essential amino acid (EAA) feed (the normal building blocks of protein) and the provision of the same dose in 4 smaller feeds at 45min intervals. The investigators will perform this study in healthy older (65-75y) and younger (18-28) men. The investigators will also explore how feeding affects muscle blood flow as this is important in the delivery of the nutrients we eat to the muscle where they are used.

The investigators plan to supplement the feed with arginine, a safe and widely found non-essential amino acid, to explore if this can improve muscle blood flow.

Conditions

  • Old Age (Focus; Not a Recognized Condition)

Interventions

DIETARY_SUPPLEMENT

15g EAA bolus

Oral; in aqueous solution

DIETARY_SUPPLEMENT

4 x 3.75g Mixed EAA Pulses

Oral; in aqueous solution

DIETARY_SUPPLEMENT

15g EAA Bolus supplemented with 3g Arginine

Oral; in aqueous solution

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Philip J Atherton, PhD · University of Nottingham

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-12-31
Primary Completion
2014-01-31
Completion
2014-01-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01735539 on ClinicalTrials.gov