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Muscle Perfusion and Protein Metabolism in Elderly

NCT00945256 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 62

Last updated 2016-02-03

Study results available
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Summary

The purpose of this study was to examine the role skeletal muscle perfusion plays in mediating muscle protein synthesis in healthy older and younger individuals. The investigators hypothesized that normalization of muscle perfusion in older men and women via exercise or infusion of a vasodilator would enhance nutritive flow and skeletal muscle protein synthesis in the elderly similar to that of their younger counterparts.

Conditions

  • Aging

Interventions

OTHER

Aerobic Exercise

45 minuties of treadmill walking was completed at 40% VO2 peak

DRUG

Sodium Nitroprusside

Sodium Nitroprusside was given in a constant infusion for 180 minutes at a rate of 0.114 ug/kg/min

DIETARY_SUPPLEMENT

Amino Acid Drink

7.5 gram Amino Acid drink

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • The University of Texas Medical Branch, Galveston

    lead OTHER

Principal Investigators

  • Melinda Sheffield-Moore, PhD · UTMB

Study Design

Allocation
RANDOMIZED
Masking
NONE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2003-05-31
Primary Completion
2008-05-31
Completion
2009-05-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00945256 on ClinicalTrials.gov