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The Effect of Potassium Bicarbonate on Bone and Several Physiological Systems During Immobilisation

NCT01509456 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2017-03-01

No results posted yet for this study

Summary

Mainly due to the absence of gravitational forces in weightlessness, astronauts suffer from an increased bone loss- negatively affecting health and vitality during a mission. The development of effective countermeasures to this loss includes many different aspects like sports but also nutrition.

Alkaline salts, abundant in fruits and vegetables, have shown to have positive effects on markers of bone turnover of postmenopausal women but also men and younger adults. With the current study the effects of a potassium bicarbonate supplementation added to a standardised, strictly controlled, definite diet of healthy, young men, should be verified within 21 days of 6°- HDT- Bedrest- the gold standard of simulating weightlessness within earthbound conditions.

Conditions

  • Bone Diseases, Metabolic
  • Acid-Base Imbalance
  • Muscular Atrophy
  • Sprains and Strains
  • Protein Metabolism
  • Body Weight Changes
  • Cardiovascular Abnormalities

Interventions

DIETARY_SUPPLEMENT

Potassium Bicarbonate

90 mmol daily, effervescent tablets 30 mmol diluted in 200 ml tab water supplemented three times a day together with the main meals for 21 days of HDT- bedrest

Sponsors & Collaborators

  • University of Trieste

    collaborator OTHER

  • University of Aarhus

    collaborator OTHER

  • European Space Agency

    collaborator OTHER

  • DLR German Aerospace Center

    lead OTHER

Principal Investigators

  • Francisca May, Dr. · German Aerospace Centre, Institute of Aerospace Medicine (DLR)

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2010-10-31
Completion
2010-10-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01509456 on ClinicalTrials.gov