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Effects of a Food Preservative on Glucose Homeostasis

NCT01179945 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 13

Last updated 2012-10-01

No results posted yet for this study

Summary

The investigators propose to examine the effects of the common food preservative sodium benzoate on blood glucose and related hormones and metabolites. If an effect is demonstrated, patients with increased diabetes risk could be counseled to avoid this preservative.

Conditions

Interventions

OTHER

benzoate containing test drinks

Subjects will consume 500ml of water with 0.5 grams of sodium benzoate, followed by a solution of 75g sugar in 500ml water with 0.5 grams sodium benzoate 3 hours later. Each solution will be consumed over 5 minutes.

OTHER

non sodium benzoate containing test drinks

Subjects will consume 500ml of water followed by a solution of 75g sugar in 500ml water 3 hours later. Each solution will be consumed over 5 minutes.

Sponsors & Collaborators

Principal Investigators

  • David S Ludwig, MD, PhD · Boston Children's Hospital

  • Vamsi Mootha, MD · Massachusetts General Hospital

  • Belinda S Lennerz, MD, PhD · Boston Children's Hospital

  • Scott Vafai, MD · Massachusetts General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-08-31
Primary Completion
2011-08-31
Completion
2011-12-31

Countries

  • United States

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01179945 on ClinicalTrials.gov