Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma
NCT00004228 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 393
Last updated 2019-08-06
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. It is not yet known which regimen of combination chemotherapy is most effective for lymphoblastic lymphoma.
PURPOSE: This randomized phase III trial is studying different regimens of combination chemotherapy to compare how well they work in treating children or adolescents with newly diagnosed stage III or stage IV lymphoblastic lymphoma.
Conditions
Interventions
- DRUG
-
asparaginase
Given IV
- DRUG
-
Given IV
- DRUG
-
Given IV
- DRUG
-
daunorubicin hydrochloride
Given IV
- DRUG
-
Given IV
- DRUG
-
doxorubicin hydrochloride
Given IV
- DRUG
-
leucovorin calcium
Given IV
- DRUG
-
mercaptopurine
Given IV
- DRUG
-
methotrexate
Given IV
- DRUG
-
Given IV
- DRUG
-
thioguanine
Given PO
- DRUG
-
vincristine sulfate
Given IV
- RADIATION
-
radiation therapy
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Children's Oncology Group
lead NETWORK
Principal Investigators
-
Minnie Abromowitch, MD · Children's Hospital Medical Center, Cincinnati
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 1 Year
- Max Age
- 30 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2000-06-30
- Primary Completion
- 2008-08-31
- Completion
- 2015-03-31
Countries
- United States
- Australia
- Canada
- Puerto Rico
- Switzerland
Study Locations
More Related Trials
-
Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia
NCT00002744 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia
NCT00005585 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy in Treating Children With Stage III or Stage IV Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia
NCT00003217 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia
NCT00002816 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy in Treating Children With Anaplastic Large Cell Lymphoma (ALCL 99)
NCT00006455 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy in Treating Children With Lymphoma
NCT00002590 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin Lymphoma
NCT01026220 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy in Treating Pediatric Patients With Stage III or IV Non-Hodgkin's Lymphoma
NCT00002691 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell Lymphoma
NCT00317408 ·Status: UNKNOWN ·Phase: NA
-
Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma
NCT01403415 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Lymphoma
NCT00302003 ·Status: COMPLETED ·Phase: PHASE3
-
Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma
NCT00275106 ·Status: TERMINATED ·Phase: PHASE3
-
Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia
NCT00049569 ·Status: COMPLETED ·Phase: NA
-
Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma
NCT00025064 ·Status: UNKNOWN ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma
NCT01230983 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy and Radiation Therapy in Treating Children With Previously Untreated Stage II, Stage III, or Stage IV Hodgkin's Disease
NCT00004010 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia
NCT00022737 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic Leukemia
NCT00003671 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes
NCT00096135 ·Status: COMPLETED ·Phase: NA
-
Treatment for Patients With Stage III or IV Non-Hodgkin Lymphoma
NCT00187122 ·Status: COMPLETED ·Phase: NA
-
Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia
NCT00002704 ·Status: COMPLETED ·Phase: PHASE2
-
Treating Young Patients With Newly Diagnosed, Low Stage, Lymphocyte Predominant Hodgkin Disease
NCT00107198 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Combination Chemotherapy With or Without Dexrazoxane in Treating Children With Hodgkin's Disease
NCT00005578 ·Status: COMPLETED ·Phase: PHASE3
-
Radiation Therapy or Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma
NCT00416377 ·Status: UNKNOWN ·Phase: NA
-
Chemotherapy With or Without Additional Chemotherapy and/or Radiation Therapy in Treating Children With Newly Diagnosed Hodgkin's Disease
NCT00025259 ·Status: COMPLETED ·Phase: PHASE3