Terapias experimentais contra o câncer vão de vacinas de mRNA a bactérias modificadas e células CAR T

Cientistas estão testando terapias experimentais contra o câncer, incluindo vacinas terapêuticas de mRNA, bactérias EcN modificadas que liberam romidepsina em camundongos e células CAR T direcionadas a macrófagos. Os resultados são promissores, mas essas abordagens ainda estão em estágios iniciais e exigem estudos em humanos.

Scientists are working on multiple experimental strategies to fight cancer, including mRNA therapeutic vaccines, engineered probiotic bacteria that act as tumor-seeking drug factories, and an experimental CAR T-cell therapy that targets tumor macrophages. The approaches remain in early development, with personalized vaccines described as promising, engineered Escherichia coli Nissle 1917 tested in mice, and the macrophage-focused therapy producing striking results in preclinical models of metastatic ovarian and lung cancer.

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References

  1. Scientists are working on a vaccine for cancer . Here's how it would work - The Hill · thehill.com
  2. Scientists turn probiotic bacteria into tumor -hunting cancer killers - ScienceDaily · sciencedaily.com
  3. Scientists Turn Cancer's Bodyguards Against It - SciTechDaily · scitechdaily.com