Lung cancer is a malignant disease that starts in lung tissue and includes two major classes: non-small cell lung cancer and small cell lung cancer. It remains one of the leading causes of cancer morbidity and mortality.
Moderna and Merck's personalized mRNA cancer vaccine, intismeran autogene, showed promising Phase 3 results in preventing melanoma recurrence. Combined with Keytruda, it cut recurrence risk by half and reduced spread by 59% in earlier data. The treatment could reach patients within two years pending regulatory approval.
AbbVie will present new lung cancer data at WCLC 2026, including Phase 1b results for ABBV-1480 showing high response rates in NSCLC and safety updates for ABBV-706 in SCLC. The company also reported progress in dermatology, obesity, and Crohn's disease programs.
IceCure Medical's ProSense cryoablation system gains IRB approval for the ChoICE post-marketing study in low-risk breast cancer, with patient enrollment expected soon. Additionally, Thomas Hospital in Alabama becomes the first facility in the state to install ProSense, with procedures starting this month.
Merck and Moderna's personalized mRNA cancer vaccine combined with Keytruda significantly reduced melanoma recurrence risk in a Phase 3 trial. The FDA has not yet approved the vaccine, with potential availability expected by early 2027.
A Chest study finds that respiratory or red flag symptoms at baseline increase the likelihood of lung cancer diagnosis within one year after screening. A Nature study identifies glucocorticoid-related genes with causal links to non-small cell lung cancer and constructs a multi-omics prognostic model.
Michelle, a mental health therapist, was diagnosed with stage 4 lung cancer and given 24 months to live. Through yoga and meditation, she shifted her mindset and is now thriving six years after diagnosis, with tumors continuing to shrink.
Johnson & Johnson agreed to buy Firefly Bio for $1 billion to advance KRAS-targeted cancer therapies. The company also announced a $1 billion cell therapy manufacturing plant in Pennsylvania as part of a $55 billion US investment plan.
A first-in-human T-cell therapy showed lasting benefit in children with DIPG and relapsed CNS tumors, while a preclinical mRNA vaccine reduced neuroblastoma tumor size by 70%. Aneuploidy predicted response to olaparib plus irinotecan.
Clinical trials show a pancreatic cancer drug nearly doubles survival, a head-and-neck therapy shrinks tumors, and new research explains drug resistance. Cancer mortality is falling in the US and UK.
AstraZeneca is expanding in China with a $200m upfront COPD drug license from Sino Biopharmaceutical, a $1.5bn licensing deal for Dizal's Zegfrovy, and a $15bn manufacturing and R&D investment. The deals add revenue-generating assets to its respiratory and oncology portfolios.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07785791 |
ERAS Compliance and Nutritional Outcomes After Lung Cancer Surgery |
RECRUITING | |
| NCT07782359 |
Impact of Using a GLP1 on Treatment Related Side Effects of Lung Cancer Patients Receiving Lorlatinib |
NOT_YET_RECRUITING | PHASE1 |
| NCT07775820 |
PD-L1 Inhibitor Rechallenge After Immunotherapy-Related Pneumonitis in Patients With Lung Cancer |
RECRUITING | |
| NCT07766538 |
Feasibility and Uptake of Low-Dose CT Lung Cancer Screening in Kuwait |
NOT_YET_RECRUITING | NA |
| NCT07760012 |
68Ga-SorB PET/CT Imaging in Patients With Solid Tumors |
RECRUITING | NA |
| NCT07740239 |
A COhort Study on Factors Leading to Vulnerability in Adult Patients With Serious Medical cOnditionS: the COSMOS-I Trial |
RECRUITING | |
| NCT07732686 |
Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry |
NOT_YET_RECRUITING | |
| NCT07720245 |
Effectiveness of a Self-health Assessment Mobile Application in Young-to-midlife Adults in Hong Kong |
RECRUITING | NA |
| NCT07720141 |
Dissemination Of Lung Cancer Screening Education Through Tobacco Quitlines |
NOT_YET_RECRUITING | NA |
| NCT07716280 |
Digital Health Implementation Strategies to Improve Lung Cancer Screening Among Safety-Net Clinics |
RECRUITING | NA |
