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Endoplasmic Reticulum Stress Response in Periodontal Disease

NCT07751419 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 72

Last updated 2026-08-07

No results posted yet for this study

Summary

Periodontal disease causes inflammation and damage to the tissues that support the teeth. This study looks at whether stress inside gum cells contributes to this damage. Cells have a stress response system that helps them deal with damaged or misfolded proteins. This study measured several markers of this cell stress response (called GRP78, PERK, IRE1, ATF6, MANF, CRELD2) along with a marker of inflammation (TNF-α). These were measured in fluid collected from around the teeth and in small samples of gum tissue.

Researchers compared 72 healthy adults who did not smoke, divided into three equal groups: people with healthy gums, people with mild gum inflammation (gingivitis), and people with a more advanced form of gum disease (periodontitis). The results showed that markers of cell stress were higher in people with periodontitis compared to the other two groups, both in the fluid around the teeth and in the gum tissue itself. This suggests that cell stress inside gum tissue may play a role in the inflammation and tissue breakdown seen in periodontitis. These findings may help researchers better understand what drives gum disease and could guide future work on new ways to detect or treat it.

Conditions

  • Periodontitis
  • Gingivitis

Sponsors & Collaborators

  • Inonu University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-15
Primary Completion
2026-02-15
Completion
2026-02-15

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07751419 on ClinicalTrials.gov