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Meteorin-like Levels in Individuals With Periodontitis

NCT04402996 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2024-04-29

No results posted yet for this study

Summary

Metrnl has proven to be an inflammatory-related immunoregulatory cytokine and shown to play a role in the pathogenesis of human inflammatory diseases. Metrnl is highly expressed from the oral mucosa to the esophagus. Periodontitis is a chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. The authors think that Metrnl may play a role in the periodontitis. The aim of this study is to compare the Metrnl, IL-1β, and IL-10 levels of healthy and periodontitis individuals.

Conditions

  • Periodontitis
  • Gingivitis
  • Healthy

Interventions

OTHER

Saliva

individuals' saliva samples will be collected and transferred to eppendorf tubes. Until biochemical analysis is carried out will be stored in -80ºC.

OTHER

gingival crevicular fluid

GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes. Until biochemical analysis is carried out will be stored in -80ºC.

Sponsors & Collaborators

  • Istanbul Saglik Bilimleri University

    lead OTHER

Principal Investigators

  • Ayşe Toraman, Dr. · Saglik Bilimleri Universitesi

  • Serhat Köseoğlu, assoc prof · Saglik Bilimleri Universitesi

  • Mehmet Sağlam, assoc prof · Izmir Katip Celebi University

  • Levent Savran, PhD · Izmir Katip Celebi University

  • Ebru Sağlam, Dr · Saglik Bilimleri Universitesi

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-09-23
Primary Completion
2021-03-03
Completion
2021-03-03

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04402996 on ClinicalTrials.gov