MedTrace Logo

(NOD)-Like Receptors CARD Domain-Containing 4 Levels in Individuals With Periodontitis

NCT04850768 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 75

Last updated 2021-04-20

No results posted yet for this study

Summary

NLRC4, an inflammasome , is a cytosolic multiprotein complex involved in the initiation and modulation of the immune response. Periodontitis is a chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. It has been said that proinflammatory cytokines released in the microenvironment of periodontitis can increase the expression of NLRC4 inflammasome genes. The authors think that NLRC4 may play a role in the periodontitis. The aim of this study is to compare the NLRC4, IL-1β and IL-10 levels of healthy and periodontitis individuals.

Conditions

  • Periodontitis
  • Gingivitis
  • Healthy

Interventions

OTHER

Saliva

individuals' saliva samples will be collected and transferred to eppendorf tubes. Until biochemical analysis is carried out will be stored in -80ºC.

OTHER

gingival crevicular fluid

GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes.Until biochemical analysis is carried out will be stored in -80ºC.

Sponsors & Collaborators

  • Saglik Bilimleri Universitesi

    lead OTHER

Principal Investigators

  • Ayşe Toraman, Dr · Saglik Bilimleri Universitesi

  • Ebru Sağlam, Dr · Saglik Bilimleri Universitesi

  • Serhat Köseoğlu, assoc prof · Saglik Bilimleri Universitesi

  • Mehmet Sağlam, assoc prof · Izmir Katip Celebi University

  • Levent Savran, PhD · Izmir Katip Celebi University

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-04-16
Primary Completion
2021-07-20
Completion
2021-09-20

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04850768 on ClinicalTrials.gov