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Non-surgical Periodontal Treatment and Periostin Levels

NCT05535049 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2023-10-11

No results posted yet for this study

Summary

Two different studies were planned from the recruited samples. The aim of these studies was to investigate the effect of non-surgical periodontal treatment on the inflammatory markers levels in serum and gingival crevicular fluid (GCF) in patients with periodontitis.

There were two groups consisting of individuals who had periodontitis and those who were healthy, with 24 individuals in each group.

Periostin levels were assessed at baseline, at the 24th h, 48th h, 14th day 1st month, 3rd month after non-surgical periodontal treatment in serum and GCF samples by the Elisa method in the first study. In parallel, interleukin 1 (IL)-beta and fibroblast growth factor levels were measured.

Progranulin levels were assessed at baseline, at the 24th h, 48th h, 14th day 1st month, 3rd month after non-surgical periodontal treatment in serum and GCF samples by the Luminex method in the second study. In parallel, vascular endothelial growth factor, IL-1 beta, tumor necrosis factor-alpha, and IL-10 levels were measured.

Conditions

  • Periodontal Treatment, Cytokines

Interventions

PROCEDURE

Non-surgical periodontal treatment

Full month non-surgical periodontal treatment procedure was applied to the periodontitis group.

Sponsors & Collaborators

  • Mustafa Kemal University

    lead OTHER

Principal Investigators

  • Aysegul Sari, PhD · Hatay Mustafa Kemal University Dental Faculty

  • Oguzhan Ozcan, Prof · Hatay Mustafa Kemal University Medical Faculty

  • Alpdogan Kantarci, Prof · Boston University Goldman School of Dental Medicine

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
24 Years
Max Age
58 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-12-01
Primary Completion
2021-08-01
Completion
2021-11-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05535049 on ClinicalTrials.gov