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Salivary Angiotensin-Converting Enzyme and Periodontal Disease in Cardiovascular Disease

NCT07721428 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 76

Last updated 2026-07-23

No results posted yet for this study

Summary

The goal of this observational study is to learn whether the renin-angiotensin system, measured by angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) in saliva and blood, is associated with periodontal disease severity in adults undergoing cardiovascular evaluation.

The main questions it aims to answer are:

* Are salivary and blood ACE and ACE2 levels different according to periodontal disease severity?
* Do salivary ACE and ACE2 levels reflect the corresponding blood levels?
* Are ACE and ACE2 levels related to clinical measures of periodontal disease?

Participants will:

* Complete medical and dental history assessments.
* Undergo a comprehensive periodontal examination, including measurements of plaque, gingival inflammation, bleeding on probing, probing pocket depth, clinical attachment loss, and the number of remaining teeth.
* Provide saliva and blood samples for laboratory measurement of ACE and ACE2.

Conditions

Sponsors & Collaborators

  • Suleyman Demirel University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-03-01
Primary Completion
2021-06-12
Completion
2026-06-01

Countries

  • Turkey (Türkiye)

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07721428 on ClinicalTrials.gov