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Relationship Between Oral Findings and Salivary Factors in Sars-Cov-2 Patients

NCT05476848 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 320

Last updated 2023-08-15

No results posted yet for this study

Summary

Two hundred individuals will be formed according to the study and control groups: Group-1: coronavirus 2 (Covid-19) (+) patients (n=100) and Group-2: Healthy individuals (in which the volunteers will be included due to group-1) (n=100). Oral examinations including DMFT scores, salivary flow rate, visible gingival index scores and radiographs (OPG) will be performed on both groups on the 1st appointment. Oral swap samples will be collected with sterile swap brushes (Six sample for each person) on the 1st, 7th and 30th days to evaluate the salivary immunoglobulins (Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin M (IgM)) and cytokine (IL-1, IL-6, IL-10) levels. Blood samples will be collected to validate the oral swap test results.

Conditions

  • Decay, Dental
  • Missing Teeth
  • COVID-19
  • Cytokine Storm

Interventions

DIAGNOSTIC_TEST

ELISA test for Cytokines

ELISA tests specific for cytokines (IL-1, IL-6, IL-10) and immunoglobulins (IgA, IgG, IgM) will be performed by a biochemistry lab, both for blood samples and oral swap samples.

Sponsors & Collaborators

  • Dokuz Eylul University

    collaborator OTHER

  • Izmir Katip Celebi University

    collaborator OTHER

  • Gazi University

    collaborator OTHER

  • Istanbul Saglik Bilimleri University

    collaborator OTHER

  • Ege University

    lead OTHER

Principal Investigators

  • Cem Peskersoy · Ege University Faculty of Dentistry

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-01
Primary Completion
2022-08-10
Completion
2023-08-10

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05476848 on ClinicalTrials.gov