Assessment of The Oral Health Status of Children With Chronic Kidney Disease

Summary

The aim of this study is to compare the oral health findings, salivary parameters and disease-related quality of life of children with different stages of Chronic Kidney Disease(CKD), those undergoing dialysis and transplantation, with healthy children, and to evaluate certain serum biomarkers in children with CKD.

Conditions

• Chronic Kidney Diseases
• Caries,Dental
• Quality of Life
• Saliva Altered
• Periodontitis

Interventions

DIAGNOSTIC_TEST

physical and chemical methods

Salivary flow rate, pH, buffering capacity

DIAGNOSTIC_TEST

biochemical methods

Total oxidant and antioxidant capacities

DIAGNOSTIC_TEST

biochemical tests

urea, calcium, potassium, phosphorus

DIAGNOSTIC_TEST

Oral Health Habits

Tooth brushing frequency Dental floss usage Annual dentist visits

DIAGNOSTIC_TEST

Oral Findings

DMFT/dft Index: Measures decayed, missing, and filled teeth. ICDAS II: International Caries Detection and Assessment System, used for detecting and assessing dental caries. DDE Index: Developmental Defects of Enamel index. BAKH Index: Basic Anatomic Keratinization Hierarchy, typically used in specific studies. DI (Debris Index): Assesses oral hygiene based on the amount of debris on the teeth. CI (Calculus Index): Measures the amount of calculus (tartar) on the teeth. OHI-S (Simplified Oral Hygiene Index): Assesses oral hygiene based on the presence of debris and calculus. MGI (Modified Gingival Index): Assesses the severity of gingivitis based on inflammation.

DIAGNOSTIC_TEST

Quality of Life Assessment

KINDLR Scale: Used to assess disease-related quality of life from both the child's and the parent's perspectives.

Sponsors & Collaborators

• Marmara University

  lead OTHER

Principal Investigators

• Harika Alpay, Prof · Marmara University Faculty of Medicine

• İbrahim Gökçe, Prof · Marmara University Faculty of Medicine

• Nurdan Yıldız, Prof · Marmara University Faculty of Medicine

• Nihal Şehkar Oktay, Assoc. Prof · Marmara University Faculty of Medicine

Eligibility

Min Age

1 Year

Max Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-08-10

Primary Completion

2023-09-06

Completion

2024-01-18

Countries

• Turkey (Türkiye)

Study Locations