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The Effects of Nitrate-Rich Mouthwash on Vascular Tone

NCT07602764 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-05-22

No results posted yet for this study

Summary

High blood pressure (hypertension) is a major risk factor for cardiovascular disease. One important contributing factor to high blood pressure is reduced availability of nitric oxide (NO). Therefore, NO is an important molecule in maintaining healthy blood vessel function.

Dietary nitrate, found in leafy greens, can serve as an alternative source of nitric oxide in the body. After ingestion, nitrate is converted to nitrite by bacteria residing in the oral cavity. Nitrite can subsequently be converted to NO when swallowed. Therefore, this nitrate-nitrite-nitric oxide pathway is dependent on oral bacteria.

This study aims to assess whether rinsing the mouth with a nitrate-rich mouth rinse influences blood pressure in healthy adults. Also, concentrations of nitrate and nitrite in plasma and saliva will be measured following the nitrate-mouth rinse exposure.

Conditions

  • Blood Pressure Regulation

Interventions

DIETARY_SUPPLEMENT

Nitrate-rich mouth rinse

The oral cavity is rinsed with nitrate from mouth rinse, rather than ingested.

DIETARY_SUPPLEMENT

Nitrate-rich drink

Nitrate is ingested, rather than rinsed and spit out

DIETARY_SUPPLEMENT

Placebo

This mouth rinse is devoid of nitrates

DIETARY_SUPPLEMENT

Placebo

This drink is devoid of nitrates

Sponsors & Collaborators

  • Göteborg University

    lead OTHER

Principal Investigators

  • Amina Basic, PhD, DDS · Göteborg University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-04-30
Primary Completion
2028-12-31
Completion
2028-12-31

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07602764 on ClinicalTrials.gov