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Nutritional Supplements and Nitric Oxide Bioactivity

NCT03625596 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2020-02-20

No results posted yet for this study

Summary

Obese people have a disturbed postprandial metabolism and thereby a decreased postprandial vascular function. Nitric oxide plays an important role in the postprandial vascular function. Multiple studies already focused on various nutritional compounds to improve the postprandial vascular function by increasing the nitric oxide bioactivity. However, the vast majority of the trials has been performed with relatively high doses of the individual components, which are problematic to convert into daily food measures, thereby preventing translation of these findings. Well-designed trails studying the effect of feasible amounts of nutritional supplements on the bioactivity of nitric oxide and vascular function are missing.

Conditions

  • Nitric Oxide
  • Vascular Function
  • L-Arginine
  • Nitrate / Nitrite
  • Postprandial Metabolism

Interventions

DIETARY_SUPPLEMENT

L-Arginine

Acute intervention (3 hours)

DIETARY_SUPPLEMENT

Nitrate / Nitrite

Acute intervention (3 hours)

DIETARY_SUPPLEMENT

Placebo

Acute intervention (3 hours)

Sponsors & Collaborators

  • Nutricia Research

    collaborator INDUSTRY

  • Maastricht University Medical Center

    lead OTHER

Principal Investigators

  • Peter J Joris, PhD · Maastricht University Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
40 Years
Max Age
70 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-12-01
Primary Completion
2019-12-31
Completion
2019-12-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03625596 on ClinicalTrials.gov