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Watermelon and Beetroot Products on Endothelial Function

NCT04781595 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2022-12-22

No results posted yet for this study

Summary

Cardiovascular disease is the main cause of death worldwide. Endothelial dysfunction is the first step to development of cardiovascular diseases. Endothelial dysfunction occurs due to reduction in nitric oxide, a molecule that plays an important role on vascular health. Due to important role of nitric oxide in endothelial function, several studies have evaluated the effect of its precursors, such as L-citrulline and nitrate on endothelial function parameters. The present study will evaluate the effect of L-citrulline and nitrate derived by watermelon and beetroot products, respectively, on endothelial function of young and older participants. Furthermore, we will evaluate the plasmatic amino acids, nitrate, glucose and insulin in response to ingestion of these products.

Conditions

  • Healthy Young
  • Older People With Cardiovascular Disease Risk

Interventions

DIETARY_SUPPLEMENT

Watermelon

A single dose of watermelon powder containing 3g of L-citrulline

DIETARY_SUPPLEMENT

Beetroot

A single dose of beetroot powder containing 8 mmol of nitrate

DIETARY_SUPPLEMENT

Watermelon + beetroot

A single dose of watermelon and beetroot powder containing 3g of L-citrulline and 8 mmol of nitrate

DIETARY_SUPPLEMENT

Placebo

A single dose of maltodextrin

Sponsors & Collaborators

  • Universidade Federal do Rio de Janeiro

    lead OTHER

Principal Investigators

  • Thiago Alvares, PhD · Universidade Federal do Rio de Janeiro

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-03-01
Primary Completion
2022-06-30
Completion
2022-07-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04781595 on ClinicalTrials.gov