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Effect of NO Precursors on Physiological Responses to Exercise

NCT02850367 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 63

Last updated 2025-12-29

No results posted yet for this study

Summary

NO is an ubiquitous molecule contributing to many physiological functions such as vasodilation, immune and oxidative stress responses. NO production can be supplemented either by providing substrate to the NO-synthase (L-Arginine and L-Citruline) or by providing nitrate which can lead to NO. In the present project the investigators evaluate the effect of various acute and chronic oral NO precursors supplementation on exercise performance and responses in healthy young and older subjects.

Conditions

  • Physiology

Interventions

DIETARY_SUPPLEMENT

Nitrate

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

DIETARY_SUPPLEMENT

Nitrate and L-Arginine

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

DIETARY_SUPPLEMENT

Nitrate and L-Citrulline

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

DIETARY_SUPPLEMENT

Placebo

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with a placebo.

BIOLOGICAL

Evaluation of post-ischemic vascular reactivity

After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS.

BIOLOGICAL

Neuromuscular evaluations

After the intake of the supplement. Measure the stretching force in the ankle (N)

Sponsors & Collaborators

  • University Hospital, Grenoble

    lead OTHER

Principal Investigators

  • Stéphane Doutreleau, PhD · University Hospital, Grenoble

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-05-09
Primary Completion
2021-09-30
Completion
2021-09-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02850367 on ClinicalTrials.gov