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The Effect of Orally Administrated Nitrate on Renal Parameters and Systemic Haemodynamics

NCT04755400 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2021-02-21

No results posted yet for this study

Summary

Treatment with nitrate has shown to lower blood pressure in both healthy subjects and hypertensive patients.Beside this nitrate have also shown to decrease arterial stiffness and improve endothelial function.But the effect of nitrate on renal blood flow, kidney function, water and salt balance and vasoactive hormones is still unclear.

Therefore, the purpose of this study is to investigate the effect of orally administered nitrate on these parameters.

This will be done in a double-blinded, placebo-controlled, crossover study. 20 healthy subjects will be treated, in a randomized order, with both potassium nitrate and placebo separated by at least 4 weeks wash-out.

Conditions

Interventions

OTHER

isotonic saline 9%

1 Liter of Isotonic saline administered I.V.

DIETARY_SUPPLEMENT

Potassium nitrate

24 mmol of Potassium nitrate is the active comparator substance, that is ingested every morning for 4 days before and on the examination day.

DIETARY_SUPPLEMENT

Potassium chloride

24 mmol of Potassium nitrate is the placebo substance, that is ingested every morning for 4 days before and on the examination day.

Sponsors & Collaborators

  • Herning Hospital

    collaborator OTHER

  • Frank Mose

    lead OTHER

Principal Investigators

  • Jesper N Bech, Ph.D., M.D. · University of Aarhus

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-09-01
Primary Completion
2020-03-15
Completion
2020-03-15

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04755400 on ClinicalTrials.gov