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The Impact of Low Sodium Salt Substitute Use on Serum Potassium Levels Among Patients With Hypertension

NCT07460882 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 607

Last updated 2026-05-08

No results posted yet for this study

Summary

The goal of this pre-post study is to assess the risk of hyperkalemia in adults with hypertension on medication in Bangladesh. The main questions it aims to answer are:

Is the risk of hyperkalemia after the initiation of Low Sodium Salt Substitute (LSSS) in people on antihypertensive medication (especially RASi) large enough to be concerned about its broad use in this population?

Does initiation of LSSS correct hypokalemia in people on antihypertensive medication (especially RASi) with low serum potassium levels?

Participants will be asked to reduce overall salt intake and to use LSSS on every occasion where regular salt would normally be used, including as cooking salt.

Conditions

Interventions

DIETARY_SUPPLEMENT

Low-sodium salt substitute

The low sodium salt substitute contains 25% potassium chloride (KCl range; 20%-35%)

Sponsors & Collaborators

  • National Heart Foundation of Bangladesh

    collaborator OTHER

  • Vital Strategies

    collaborator OTHER

  • Johns Hopkins University

    lead OTHER

Principal Investigators

  • Junichi Ishigami, MD, PhD · Johns Hopkins University

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-01
Primary Completion
2027-03-31
Completion
2027-09-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07460882 on ClinicalTrials.gov