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Mechanisms Underlying the Protective Vascular Effects of Dietary Potassium in Humans

NCT04101188 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2026-03-04

No results posted yet for this study

Summary

Americans continue to consume high amounts of sodium. Potassium is notable for its blood pressure lowering effects but less is known regarding its effect on the vasculature. This investigation seeks to determine the role of dietary potassium on the vasculature in the presence of a high sodium diet in salt-resistant adults.

Conditions

  • Cardiovascular Risk Factor

Interventions

OTHER

Moderate Potassium/Low Sodium Diet

Consumption of 10 days of a diet moderate in potassium and low in sodium.

OTHER

Moderate Potassium/High Sodium Diet

Consumption of 10 days of a diet moderate in potassium and high in sodium.

OTHER

High Potassium/High Sodium Diet

Consumption of 10 days of a diet high in potassium and high in sodium.

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of Delaware

    lead OTHER

Principal Investigators

  • Shannon L Lennon, PhD · University of Delaware

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-01-16
Primary Completion
2026-07-31
Completion
2026-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04101188 on ClinicalTrials.gov