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Neurokinin A and Matrix Metalloproteinase 9 Levels in Gingival Crevicular Fluid Samples of Teeth With Symptomatic Irreversible Pulpitis With Symptomatic Apical Periodontitis

NCT07289074 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 23

Last updated 2025-12-17

No results posted yet for this study

Summary

The aim of this study is to investigate the levels Neurokinin A and of Matrix Mtalloproteinase (MMP-9) in gingival crevicular fluid samples (GCF) as potential biomarkers for the diagnosis of symptomatic irreversible pulpitis with symptomatic apical periodontitis and to correlate the level of these diagnostic biomarkers ( Nerokinin A and MMP-9) with the pre-operative pain severity using the Numerical Rating Scale (NRS).

This study will utilize a comparative cross-sectional design to assess the levels of Neurokinin A (NKA) and Matrix metalloproteinase-9 (MMP-9) in gingival crevicular fluid (GCF) samples from symptomatic and healthy contralateral teeth with normal pulp.

Conditions

  • Symptomatic Irreversible Pulpitis With Apical Peridontitis

Interventions

DIAGNOSTIC_TEST

Gingival crevicular fluid samples from the symptomatic teeth and the healthy contrlateral teeth

The detection of the inflammatory biomarkers levels in the gingival crevicular fluid of the symptomatic teeth is considered an objective,molecular-based and non invasive method for diagnosis.

Sponsors & Collaborators

  • Hadeer Mostafa El Mohamady El Feky

    lead OTHER

Principal Investigators

  • Saied M Abdel Aziz, Professor of Endodontics · Faculy of Dentistry, Cairo university, Egypt

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-28
Primary Completion
2026-09-30
Completion
2026-11-30

Countries

  • Egypt

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07289074 on ClinicalTrials.gov