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Cytokine and MMP Levels in Gingival Crevicular Fluid in the Treatment of Localized Gingival Recessions

NCT02380872 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2015-03-05

No results posted yet for this study

Summary

The main objective of this study was to evaluate the matrix metalloproteinase (MMP)-8, and -9, tissue inhibitor of matrix metalloproteinase and interleukin-1beta levels in gingival crevicular fluid during the early and late stages of healing for gingival recession sites treated by coronally advanced flap plus platelet rich fibrin (PRF) compared to CAF plus connective tissue graft. As PRF consists of several growth factors, it may enhance the healing potential of soft tissues, the investigators hypothesized that using PRF in the treatment of gingival recessions might regulate inflammation and promote wound healing.

Conditions

  • Gingival Recession

Interventions

PROCEDURE

Connective tissue graft

gingival recession treated with connective tissue graft

PROCEDURE

Platelet Rich Fibrin

gingival recession treated with platelet rich fibrin

Sponsors & Collaborators

  • Ege University

    lead OTHER

Principal Investigators

  • Gülnihal Eren, PhD. Dr. · Ege University School of Dentistry

  • Gül Atilla, Professor · Ege University School of Dentistry

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-10-31
Primary Completion
2013-09-30
Completion
2013-10-31

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02380872 on ClinicalTrials.gov