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Activated MMP-8 as Diagnostic Test for Periodontitis

NCT02280122 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2015-07-13

Study results available
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Summary

Background: Untreated periodontal disease may influence general health. However, how may a physician who is not trained in periodontal probing detect untreated periodontitis? Activated matrix metalloproteinase-8 (aMMP-8) in saliva correlates with periodontal probing parameters. Thus, sensitivity and specificity of a chair-side test for activated matrix metalloproteinase-8 to detect periodontitis was evaluated.

Methods: Thirty cases (untreated chronic periodontitis; 15 generalized moderate and 15 generalized severe) and 30 controls (probing pocket depths ≤ 3 mm, vertical probing attachment level ≤ 2 mm at \< 30% of sites) were examined periodontally. Further, the activated matrix metalloproteinase-8 test was performed. The test kit becomes positive with ≥ 25 ng/ml activated matrix metalloproteinase-8 in the sample.

Conditions

  • Generalized Chronic Periodontitis

Interventions

OTHER

no intervention provided

No Intervention was rendered but the aMMP-8 test was made

Sponsors & Collaborators

  • Goethe University

    lead OTHER

Principal Investigators

  • Peter Eickholz, Dr. · Johann Wolfgang Goethe-Universität

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-09-30
Primary Completion
2014-02-28
Completion
2014-02-28

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02280122 on ClinicalTrials.gov