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Interleukin 8 and10 Levels Changes in Teeth With Necrotic Pulp and Apical Periodontitis

NCT06713174 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2026-02-18

No results posted yet for this study

Summary

The goal of this observational study is to evaluate changes in interleukin 8 (IL-8) and interleukin 10 (IL-10) levels in gingival crevicular fluid (GCF) and periapical fluid during root canal treatment in patients with necrotic pulp and apical periodontitis. The main question it aims to answer is:

How do IL-8 and IL-10 levels in GCF and periapical fluid change over the course of treatment?

Participants will:

Provide samples of GCF and periapical fluid at two different time points during their root canal treatment.

Undergo treatment based on standard clinical protocols for necrotic pulp and apical periodontitis.

Conditions

  • Pulp and Periapical Tissue Disease
  • Patients With Pulp Necrosis and Apical Periodontitis

Interventions

DIAGNOSTIC_TEST

Assessment of Interleukin 8 and 10 Level Changes Before and During Root Canal Treatment for Necrotic Pulp with Apical Periodontitis

This study will be performed to investigate interleukin-8 (IL-8) and interleukin-10 (IL-10) level changes in gingival crevicular fluid (GCF) and periapical fluid before and during root canal treatment (RCT) in patients with necrotic pulp and apical periodontitis. The null hypothesis tested will be There is no significant difference in (IL-8) and (IL-10) levels in gingival crevicular fluid (GCF) and periapical before and during root canal treatment (RCT) for necrotic pulp with apical periodontitis.

Sponsors & Collaborators

  • Faculty of Dental Medicine for Girls

    lead OTHER_GOV

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-12-15
Primary Completion
2025-01-15
Completion
2025-03-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06713174 on ClinicalTrials.gov