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Asprosın And Tumor Necrosıs Factor-α Levels In Type 2 Dıabetıc Chronıc Periodontitis

NCT06993818 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 102

Last updated 2025-05-29

No results posted yet for this study

Summary

Periodontal disease is a chronic, multifactorial inflammatory disease in which biochemical and cellular events trigger each other, leading to the destruction of the tissues supporting the teeth . The pathogenesis of the disease is a dynamic process that develops as a result of complex interactions between pathogenic bacteria and the host response . There is a bidirectional relationship between diabetes mellitus (DM), which is among the systemic diseases that negatively affect the host immune response, and periodontal disease. In the case of DM, long-term hyperglycemia causes proteins to react irreversibly with glucose, resulting in the formation of advanced glycation end products (AGEs). It is suggested that increased AGE levels increase cytokine secretion against periodontopathogens, exacerbate inflammatory tissue destruction, and may negatively affect biological functions through cell-cell and cell-matrix interactions in the connective tissue.

The present study was conducted to gain further insight into the role of CGF and serum Asprosin level in the pathogenetic processes linking DM and periodontal disease.

Conditions

  • Periodontal Diseases

Interventions

OTHER

Gingival Crevicular Fluid

Periodontal clinical parameters and examination of asprosin levels in gingival crevicular fluid and serum samples

DIAGNOSTIC_TEST

Serum Asprosin

Periodontal clinical parameters and examination of asprosin levels in gingival crevicular fluid and serum samples

Sponsors & Collaborators

  • Eda Cetin Ozdemir

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-11-01
Primary Completion
2025-04-01
Completion
2025-04-15

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06993818 on ClinicalTrials.gov