The NUTRIOME Study - a Data-driven Precision Nutrition Intervention

Summary

The overall objective of this multi-center study is to use metabolic response data from different dietary challenges to develop personalized dietary advice. Effectiveness of this personalized dietary advice compared to a general healthy diet based on national dietary guidelines on markers of cardio-metabolic health will be tested.

A total of 120 men and women who meet all inclusion criteria and none of the exclusion criteria will be invited to participate. The study will be conducted at three sites: Chalmers University of Technology (Sweden), University of Wageningen (Netherlands), and University of Oslo (Norway), with 40 participants per site.The study is conducted in two parts. The first part, the characterization phase, is a three-way randomized, controlled cross-over design, featuring one-day meal tests with isocaloric meals containing different carbohydrate, fat and protein quantity as well as quality. Based on the metabolic response to the meal tests a personalized diet will be constructed. In the second part, the main intervention, effectiveness of this personalized dietary advice compared to a general healthy diet will be tested in a six week parallel group intervention study.

Conditions

• Metabolic Control

Interventions

OTHER

General healthy diet

General healthy diet based on national health dietary guidelines.

OTHER

Personalized diet

Personalized diet will be based on an algorithm considering the individuals' postprandial glucose, triglycerides and inflammation markers to each of the three study meals in the characterization phase (Phase I) matched with established knowledge about the effects of specific foods on such metabolic parameters.

Sponsors & Collaborators

• University of Oslo

  collaborator OTHER

• Wageningen University

  collaborator OTHER

• Polish Academy of Sciences

  collaborator OTHER

• Maastricht University

  collaborator OTHER

• German Cancer Research Center

  collaborator OTHER

• University of Copenhagen

  collaborator OTHER

• University of Oulu

  collaborator OTHER

• University College Dublin

  collaborator OTHER

• Chalmers University of Technology

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

40 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-03-14

Primary Completion

2026-06-30

Completion

2026-06-30

Countries

• Netherlands
• Norway
• Sweden

Study Locations