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Neurogenic Inflammation in Peri-implant and Periodontal Diseases

NCT03663140 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 39

Last updated 2018-09-13

No results posted yet for this study

Summary

Regulatory effects of some neuropeptides substance-P (SP), neurokinin-A (NKA), calcitonin gene-linked peptide (CGRP) and neuropeptide-Y (NPY) )on inflammatory responses in periodontal disease has been described; however, the impact of neuropeptide levels are not clearly defined in healthy and diseased peri-implant tissues.ın order to evaluate the situation, thirty-nine implants that have been loaded over the past 12 months and their symmetrically matching teeth were evaluated using a split-mouth study design. Clinical periodontal examinations included the Silness-Löe plaque index, Löe-Silness gingival index, bleeding on probing, probing pocket depth and clinical attachment level parameters were determined. Gingival crevicular fluid (GCF)/Periimplant sulcular fluid (PISF) samples were collected, and the levels of the neuropeptides were determined by enzyme-linked immunosorbent assay. Correlations between GCF/PISF neuropeptide levels and the clinical examination parameters were evaluated in the peri-implant/periodontal soft tissues.

Conditions

  • Neurogenic Inflammation
  • Periimplant Diseases
  • Periodontal Diseases
  • Gingival Crevicular Fluid
  • Periimplant Sulcular Fluid

Interventions

DIAGNOSTIC_TEST

gingival crevicular fluid (GCF) and peri-implant sulcular fluid(PISF) collection

GCF/PISF samples were collected using periopaper strips. Prior to sample collection, each site was gently air-dried, all supragingival plaque was removed, and the area was carefully isolated to prevent samples from being contaminated by saliva.

Sponsors & Collaborators

  • Ondokuz Mayıs University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-01-01
Primary Completion
2013-09-15
Completion
2013-12-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03663140 on ClinicalTrials.gov