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Effect of Smoking on Saliva Composition and the Development of Dental Erosion

NCT04208802 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2026-01-27

No results posted yet for this study

Summary

The aim of this study is to investigate whether smoking is associated with changes in salivary composition and/or predisposition to erosion.

Healthy volunteers are observationally wearing an intraoral device with both bovine tooth specimens (enamel and dentin) and resin specimens twice for two hours each. Afterwards, specimens are eroded extraorally and calcium release into the acid is measured.

Total protein concentration and protein composition of the salivary pellicles on the resin samples are measured. Additionally, salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, total protein content and protein composition as well as concentration of inorganic calcium, phosphate, and fluoride) are measured.

Conditions

  • Dental Erosion

Interventions

OTHER

Use of fluoridated toothpaste

Use of fluoridated toothpaste

OTHER

Wearing of an intraoral device with bovine tooth samples

Wearing of an intraoral device with bovine tooth samples

OTHER

Wearing of an intraoral device with resin samples

Wearing of an intraoral device with resin samples

Sponsors & Collaborators

  • University of Göttingen

    lead OTHER

Principal Investigators

  • Annette Wiegand, Prof. Dr. med. dent. · Dept. of Prev. Dentistry, Periodontology and Cariology, University Medical Center Göttingen, Germany

Eligibility

Min Age
20 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-09-24
Primary Completion
2022-07-29
Completion
2022-07-29

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04208802 on ClinicalTrials.gov