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Effect of Oleactiv® on LDL Oxidability

NCT05221346 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2022-12-07

No results posted yet for this study

Summary

Oleactiv® have previously demonstrated beneficial effects in an animal model of diet-induced atherosclerosis. After a 12-week supplementation, a substantial reduction of aortic fatty streak area has been observed. Also, Oleactiv®-supplemented hamsters displayed significant decrease of both non-HDL-cholesterol and triglycerides levels. Also, phenolic compounds from Oleactiv® demonstrated that increase of cholesterol efflux capacity (CEC) is one of the mechanisms that may explain preventive effect on atheroma development.

These effects observed in animals will thus be investigated in human. The main hypothesis of the present study is that phenolic compounds from Oleactiv® may improve LDL oxidability in volunteers with moderate hypercholesterolemia after 3 weeks of consumption.

Conditions

Interventions

DIETARY_SUPPLEMENT

Plant food supplement

Food supplements are consumed during 3 weeks by hypercholesterolemic volunteers

DIETARY_SUPPLEMENT

Maltodextrin

Food supplements are consumed during 3 weeks by hypercholesterolemic volunteers

Sponsors & Collaborators

  • Institut Pasteur de Lille

    lead OTHER

Principal Investigators

  • Jean-Michel Lecerf, MD · Institut Pasteur de Lille - NutrInvest

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
40 Years
Max Age
70 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-12-13
Primary Completion
2022-10-11
Completion
2022-10-11

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05221346 on ClinicalTrials.gov