The Effect of Algae Oil Supplements on Functional Immune Response and Bioavailability of Lipids in Blood, a Pilot Study

Summary

In this explorative study we will investigate whether two sustainable oil supplements yield equivalent results to fish oil supplements in terms of postprandial immune response, among elderly adults, after standardization of the quantity of DHA among the oils. Results on the bioavailability of DHA from different oil supplements will help determine whether differences in DHA bioavailability lead to differences in immune function. Additionally, we will investigate postprandial inflammatory markers. The outcomes of this exploratorive study will provide insight into the variation between individuals and potential effect sizes, and will aim to conduct more targeted follow-up studies on the effects of algae oils on immune function.

Conditions

• Functional Immune Response
• Postprandial Bioavailability DHA
• Fatty Acid Metabolism

Interventions

DIETARY_SUPPLEMENT

Algae oil 1

DHA Origins 550-Y oil (Fermentalg)

DIETARY_SUPPLEMENT

Algae oil 2

Oleo H-02 (Microalgas)

DIETARY_SUPPLEMENT

Fish oil (control)

Tuna oil

Sponsors & Collaborators

• Nutricia Research

  collaborator INDUSTRY

• Fermentalg

  collaborator UNKNOWN

• Microalgas Oleas de México, S.A. de C.V.

  collaborator UNKNOWN

• Utrecht University

  collaborator OTHER

• Maartje van den Belt

  lead OTHER

Principal Investigators

• Maartje van den Belt, MSc · Wageningen Food and Biobased Research

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

QUADRUPLE

Model

CROSSOVER

Eligibility

Min Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-09-22

Primary Completion

2025-11-14

Completion

2025-11-14

Countries

• Netherlands

Study Locations