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Effect of Polyphenols on Absorption of Iron From Sodium Iron Chlorophyllin

NCT04849832 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2021-11-26

No results posted yet for this study

Summary

Polyphenols present in tea are known to inhibit the absorption of non heme iron. The inhibiting effect of tea on non-heme iron absorption is attributed to the flavonoids present in tea. It is well known that Ferrous sulfate is not absorbed well in the presence of polyphenols. We would like to evaluate the effect of polyphenols on the newly developed compound, sodium iron chlorophyllin (SIC), which mimics the heme iron structure. Comparisons of fractional absorption of SIC and Ferrous Sulfate in the presence of polyphenols can help identify the performance of the compounds as vehicles for iron delivery in the presence of iron absorption inhibitors.

In a single-blind randomized cross-over study using stable iron isotope technique, iron bioavailability from SIC delivered with an inhibitory matrix can therefore be determined when given along with black tea

Conditions

  • Iron-deficiency

Interventions

DIETARY_SUPPLEMENT

SIC

Sodium Iron Chlorophyllin as prepared by the human nutrition laboratory, ETH Zurich

DIETARY_SUPPLEMENT

SIC + tea

Sodium Iron Chlorophyllin as prepared by the human nutrition laboratory, ETH Zurich with 2g of tea brewed for 5 minutes

DIETARY_SUPPLEMENT

FeSO4

Ferrous sulfate solution serves as a positive control - and whose absorption is well known.

DIETARY_SUPPLEMENT

FeSO4 + tea

Ferrous sulfate solution given with 2g of tea brewed for 5 minutes - expected iron absorption inhibition

Sponsors & Collaborators

  • Swiss Federal Institute of Technology

    lead OTHER

Principal Investigators

  • Jessica Farebrother, Dr.Sc · ETH Zurich

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-06-21
Primary Completion
2021-07-26
Completion
2021-07-26

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04849832 on ClinicalTrials.gov