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Combination Treatment With Green Tea Extract and Statins in Patients With Hypercholesterolemia

NCT00944827 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2010-12-03

No results posted yet for this study

Summary

There is a positive correlation between serum's cholesterol levels and death from cardiovascular disease, especially coronary artery disease. The reduction of plasma lipids levels is one of the main goals of prevention. Research has shown that green tea has beneficial effects on health due to the polyphenolic substances (catechins) that it contains. Studies have shown that prolonged consumption of polyphenols has a positive effect on factors related to cardiovascular risk such as obesity, dislipidemia and various indicators of oxidative stress.

The aim of this study was to examine the possible effects of catechin supplementation, in combination with the classic treatment for the reduction of hypercholesterolemia, statin therapy, on the treatment's effectiveness and in the reduction of classic side effects.

Conditions

Interventions

DIETARY_SUPPLEMENT

Green Tea Extract - Catechins

Combination treatment with 20 mg atorvastatin and 600mg green tea extract, daily for 12 weeks

DIETARY_SUPPLEMENT

Placebo

Combination treatment with 20 mg atorvastatin and 600mg placebo, daily for 12 weeks

Sponsors & Collaborators

  • Greek Ministry of Development

    collaborator OTHER_GOV

  • General Hospital of Trikala, Dept of Internal Medicine

    collaborator UNKNOWN

  • University General Hospital of Larissa, Dept of Medicine

    collaborator UNKNOWN

  • University of Thessaly

    lead OTHER

Principal Investigators

  • Giorgos K Sakkas, PhD · UTH - CERETETH

  • Christina Karatzaferi, PhD · University of Thessaly

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-09-30
Primary Completion
2009-10-31
Completion
2009-10-31

Countries

  • Greece

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00944827 on ClinicalTrials.gov