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Cold Induced Futile Cycles In White Adipose Tissue

NCT04614116 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2022-03-31

No results posted yet for this study

Summary

Investigation of futile cycles in white adipose tissue under cold conditions for thermogenesis using two substitutes for glucose metabolism (18F-FDG and 13C-Glucose).

Conditions

  • Metabolism Disorder

Interventions

OTHER

External cooling

water-circulating cooling/warming sleeves connected to a medical cooling device (Hilotherm Clinic®, Hilotherm GmbH, Germany) will be placed around the subject's abdomen and lower back. Initially the temperature of the water will be set to 25°C. A mild cold stimulus will be applied by reducing the temperature of the circulating water by approximately 1°C every 2 minutes to a minimum of 10°C.

DIAGNOSTIC_TEST

FDG PET/CT

o 75 MBq 18F-FDG will be injected through the intravenous line on the scanner manually (bolus injection) with a simultaneous start of dynamic FDG-PET/CT scan for 45 minutes and a partial body scan from head to the abdomen after 45 minutes. Total scan time 60 minutes.

DIAGNOSTIC_TEST

13C-Glucose injection

0.5 g 13C-Glucose i.v. infusion over 5 minutes, after termination of FDG injection

Sponsors & Collaborators

  • Kantonsspital Baden

    lead OTHER

Principal Investigators

  • Irene A. Burger, MD · Kantonsspital Baden

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-06-15
Primary Completion
2022-02-17
Completion
2022-03-29

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04614116 on ClinicalTrials.gov