Investigating Brown Adipose Tissue Activation in Humans

Summary

The purpose of this study is to determine what can activate brown adipose tissue (BAT).

Conditions

• Metabolic Diseases

Interventions

OTHER

Period 1 Visit 1 - Cold PET-CT Vehicle, Visit 2 -Warm PET-CT Vehicle

Temperature

DRUG

Period 1 Visit 1 - Cold PET-CT Vehicle, Visit 2 -Warm PET-CT Glucagon

Hormone

OTHER

Period 1 Visit 1 - Cold PET-CT Vehicle, no visit 2 as BAT negative

Temperature

DRUG

Period 2 - Visit 1 Warm Control vehicle, Visit 2 Warm Glucagon, Visit 3 Cold control

Hormone

DRUG

Period 2 - Visit 1 Warm Glucagon, Visit 2 Cold control , Visit 3 Warm control

Hormone

DRUG

Period 2 -Visit 1 cold control, Visit 2 warm control, Visit 3 Warm glucagon

hormone

DRUG

Period 2 -Visit 1 cold control, visit 2 warm glucagon, visit 3 warm control

hormone

DRUG

Period 2- Visit 1 Warm glucagon, visit 2 warm control, visit 3 cold control

hormone

DRUG

Period 2 - Visit 1 Warm control, visit 2 cold control, visit 3 warm glucagon

Hormone

Sponsors & Collaborators

• Imperial College London

  lead OTHER

Principal Investigators

• Waljit Dhillo · Imperial College London

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-07-31

Primary Completion

2018-11-05

Completion

2018-11-05

Countries

• United Kingdom

Study Locations