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Brown Adipose Tissue as Nutrient Buffer Through Diet Induced Thermogenesis

NCT06078345 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-11-25

No results posted yet for this study

Summary

To test the hypothesis that active BAT improves metabolic health by buffering postprandial metabolites plasma metabolites and energy expenditure will be compared in volunteers with and without active BAT. Both groups will receive test meals with protein, fat and carbohydrates separately, so that the individual impacts of these macronutrients on diet induced thermogenesis and the buffering function of BAT can be derived. BAT biopsies will be taken before and after the test meals for molecular analysis.

Conditions

  • Brown Adipose Tissue
  • Metabolic Disease

Interventions

OTHER

Carbohydrate

400 Kcal glucose (100g oGTT)

OTHER

Fat

400 Kcal glucose rapeseed oil.

OTHER

Protein

400 Kcal Moltein PURE (111g)

Sponsors & Collaborators

  • ETH Zurich (Switzerland)

    collaborator OTHER

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Matthias J Betz, MD · University Hospital, Basel, Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-12
Primary Completion
2025-08-15
Completion
2025-08-15

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06078345 on ClinicalTrials.gov