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Investigation of the Relationship Between Peripheral and Central Metabolic Changes Caused by Fasting

NCT07178106 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2025-09-17

No results posted yet for this study

Summary

Fasting has become an increasingly popular intervention for improving both physical and mental health. This study aims to explore the biological mechanisms underlying the positive effects of low caloric fasting (Wilhelmi-Buchinger-fasting). Specifically, we focus on the metabolic transition from glucose to fat utilization and its effects on systemic and brain metabolism. By examining the relationship between peripheral metabolic changes and brain metabolism, this research aims to uncover how these shifts influence brain metabolism and behaviour.

Conditions

  • Healthy

Interventions

OTHER

Fasting

Participants undergo the standardised Wilhelmi-Buchinger fasting intervention, which consists of two days of preparation with a dietary energy supply of \<1000 kcal, three days of fasting with a dietary energy supply of 300-500 kcal with tea, broth, fruit and vegetable juices, and two days of recovery.

Sponsors & Collaborators

  • University Hospital, Bonn

    collaborator OTHER

  • Johann Wolfgang Goethe University Hospital

    collaborator OTHER

  • Nils Opel

    lead OTHER

Principal Investigators

  • Sharmili Edwin Thanarajah, PD Dr med · Goethe University

  • Nils Gassen, Prof Dr · University Hospital, Bonn

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-10-04
Primary Completion
2024-11-28
Completion
2024-11-28

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07178106 on ClinicalTrials.gov